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Energy & MetabolismEvidence 1B
rs7903146 · TCF7L2
Risk allele: T
Risk-Allele Phenotype
TCF7L2 transcription factor variant; strongest T2D susceptibility locus (1.5x risk per allele); affects glucose homeostasis and incretin response.
Reference-Allele Phenotype
Normal Wnt signaling and β-cell function.
Evidence Level
1B — Strong — single high-quality study See methodology for how we grade evidence.
Cross-References
Informational only
This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.
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