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CardiovascularEvidence 1A
rs7412 · APOE
Risk allele: T
Risk-Allele Phenotype
APOE ε2 allele (T allele); associated with lower LDL cholesterol but may affect atherosclerosis progression differently; ε2/ε3 intermediate lipid profile.
Reference-Allele Phenotype
APOE ε3/ε3 is the most common baseline genotype with standard lipid metabolism.
Evidence Level
1A — Strong — multiple high-quality studies See methodology for how we grade evidence.
Cross-References
Informational only
This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.
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