Back to Variant Registry
CardiovascularEvidence 1A
rs6025 · F5
Risk allele: A
Risk-Allele Phenotype
Factor V Leiden variant; heterozygotes have 3-5x increased VTE risk, homozygotes up to 80x risk; impaired anticoagulation by protein C.
Reference-Allele Phenotype
Normal Factor V anticoagulant regulation and thrombotic balance.
Evidence Level
1A — Strong — multiple high-quality studies See methodology for how we grade evidence.
Cross-References
Informational only
This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.
Want to know your status at rs6025?
Upload your DNA file — Atlagene checks this variant and 700+ others across 21 health categories.
Get Started Free