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Athletics & FitnessEvidence 2A
rs4680 · COMT
Risk allele: A
Risk-Allele Phenotype
A allele (Met158) reduces COMT enzyme activity, increasing dopamine and norepinephrine levels; associated with better stress tolerance but potential exercise anxiety.
Reference-Allele Phenotype
G allele (Val158) produces faster catecholamine degradation and lower baseline stress hormones.
Evidence Level
2A — Moderate — meta-analysis See methodology for how we grade evidence.
Cross-References
Informational only
This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.
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