Athletics & FitnessEvidence 2B

rs429358 · APOE

Risk allele: C

Risk-Allele Phenotype

C allele (APOE ε4) increases cholesterol metabolism demands and may impair recovery from intense training through altered lipid dynamics.

Reference-Allele Phenotype

T allele (APOE ε3) maintains efficient cholesterol processing and recovery.

Evidence Level

2B — Moderate — single replicated study See methodology for how we grade evidence.

Cross-References

dbSNP — rs429358
ClinVar — search rs429358
NCBI Gene — APOE

Informational only

This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.

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