PharmacogenomicsEvidence 1A

rs4244285 · CYP2C19

Risk allele: A

Risk-Allele Phenotype

CYP2C19*2 loss-of-function (splicing defect); poor metabolizer; reduced clopidogrel activation leading to stent thrombosis risk; increased omeprazole/pantoprazole levels; reduced escitalopram/citalopram metabolism.

Reference-Allele Phenotype

Normal CYP2C19 activity and prodrug activation.

Evidence Level

1A — Strong — multiple high-quality studies See methodology for how we grade evidence.

Cross-References

dbSNP — rs4244285
ClinVar — search rs4244285
NCBI Gene — CYP2C19
PharmGKB — rs4244285

Informational only

This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.

Want to know your status at rs4244285?

Upload your DNA file — Atlagene checks this variant and 700+ others across 21 health categories.

Get Started Free