AllergieseosinophilicEvidence 4Physician review

rs2524099521 · JAK1

Risk-Allele Phenotype

JAK1 rs2524099521 — associated with increased risk of autoinflammation, immune dysregulation, and eosinophilia, consistent with a gain-of-function pathogenic variant in the JAK-STAT signaling pathway.

Reference-Allele Phenotype

Normal JAK1 function at this locus, with no identified pathogenic variant associated with autoinflammatory or eosinophilic disease.

Evidence Level

4 — Preliminary See methodology for how we grade evidence.

Cross-References

dbSNP — rs2524099521
ClinVar — search rs2524099521
NCBI Gene — JAK1

Informational only

This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.

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