rs1815739 · ACTN3
Risk allele: T
Risk-Allele Phenotype
T allele (577X stop codon) produces non-functional alpha-actinin-3 protein; XX genotype lacks functional ACTN3 (R577X null) in fast-twitch muscle fibers, favoring endurance phenotype and reducing power/sprint performance.
Reference-Allele Phenotype
C allele produces functional ACTN3 (R577 wild-type) supporting fast-twitch muscle contractility and power output.
Evidence Level
1B — Strong — single high-quality study See methodology for how we grade evidence.
Cross-References
Informational only
This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.
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