rs1801133 · MTHFR
Risk allele: A
Risk-Allele Phenotype
MTHFR rs1801133 — associated with altered drug response related to methotrexate — Chronic myelogenous leukemia, BCR-ABL1 positive;Graft vs Host Disease;Leukemia. This variant may influence medication efficacy or adverse reaction risk.
Reference-Allele Phenotype
Normal MTHFR function at this locus, with no elevated genetic risk contribution to methotrexate — Chronic myelogenous leukemia, BCR-ABL1 positive;Graft vs Host Disease;Leukemia from this variant.
Evidence Level
2A — Moderate — meta-analysis See methodology for how we grade evidence.
Cross-References
Informational only
This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.
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