NutritionEvidence 1A

rs1800562 · HFE

Risk allele: A

Risk-Allele Phenotype

C282Y (Y allele) causes the most common form of hereditary hemochromatosis, leading to excessive iron absorption, cirrhosis, cardiac arrhythmias, and diabetes risk.

Reference-Allele Phenotype

C allele maintains normal hepcidin regulation and physiologic iron absorption.

Evidence Level

1A — Strong — multiple high-quality studies See methodology for how we grade evidence.

Cross-References

dbSNP — rs1800562
ClinVar — search rs1800562
NCBI Gene — HFE

Informational only

This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.

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