CardiovascularEvidence 1A

rs1799963 · F2

Risk allele: G

Risk-Allele Phenotype

Prothrombin G20210A variant; heterozygotes have 2-3x increased VTE and arterial thrombosis risk; elevated prothrombin levels.

Reference-Allele Phenotype

Normal prothrombin synthesis and coagulation cascade.

Evidence Level

1A — Strong — multiple high-quality studies See methodology for how we grade evidence.

Cross-References

dbSNP — rs1799963
ClinVar — search rs1799963
NCBI Gene — F2

Informational only

This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.

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