NutritionEvidence 1B

rs1799945 · HFE

Risk allele: A

Risk-Allele Phenotype

H63D polymorphism (A allele) increases iron absorption risk, particularly concerning when combined with C282Y; associated with elevated ferritin and iron overload in homozygotes.

Reference-Allele Phenotype

G allele maintains normal iron absorption regulation.

Evidence Level

1B — Strong — single high-quality study See methodology for how we grade evidence.

Cross-References

dbSNP — rs1799945
ClinVar — search rs1799945
NCBI Gene — HFE

Informational only

This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.

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