PharmacogenomicsEvidence 1A

rs1799853 · CYP2C9

Risk allele: C

Risk-Allele Phenotype

CYP2C9*2 variant (Arg144Cys); ~40% reduced enzyme activity; intermediate metabolizer for warfarin (requires lower dose); increased bleeding risk with standard dosing.

Reference-Allele Phenotype

Normal warfarin metabolism and clearance.

Evidence Level

1A — Strong — multiple high-quality studies See methodology for how we grade evidence.

Cross-References

dbSNP — rs1799853
ClinVar — search rs1799853
NCBI Gene — CYP2C9
PharmGKB — rs1799853

Informational only

This page summarizes population-level evidence about a genetic variant. It is not a diagnosis. Your individual risk depends on your full genome, lifestyle, environment, and family history. Consult a healthcare provider for personalized medical advice.

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